The current report aims to provide stakeholders with an analytical base helping to strengthen cross-regional cooperation mechanisms to boost the deployment of Key Enabling Technologies in Europe. The report specifically aims to highlight the value chain structure, key players and constraints for the domain of cyber-physical production systems (CPPS), and more specifically cyber-physical systems for production monitoring, with a particular attention to the less developed regions in Eastern and Southern Europe. It also addresses the key strengths and potential of the EU regions, as well as promising business opportunities and key risks and challenges. Finally, the report elaborates on specific policy recommendations with both immediate focus and longer-term orientation.